Figure 2

Detection of IDH mutations in cerebrospinal fluid: A discussion of liquid biopsy in neuropathology

Ming Lee*, Gek San Tan, Chee Kian Tham and Kiat-Hon Tony Lim

Published: 17 September, 2020 | Volume 4 - Issue 1 | Pages: 011-023

apcr-aid1018-g002

Figure 2:

2: A representation of tumour components transported from a glioma into CSF and peripheral blood. (A) GBM disrupts the BBB allowing circulating biomarkers to enter peripheral blood. Alternatively, tumour proximity to a CSF-containing space obviates the need for passage through the BBB, allowing a potentially higher yield in CSF. (B) Detailed composition of the tumoural components detectable in the circulation. Several classes of molecules can be captured and studied, including CTC’s, extracellular vesicles, ct-DNA, mRNA and miRNA. These carry information such as mutational status, epigenetic changes such as methylation, and chromosomal abnormalities which can be sampled non-invasively.

Read Full Article HTML DOI: 10.29328/journal.apcr.1001018 Cite this Article Read Full Article PDF

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