Abstract

Case Report

Clinical and Histopathological Mismatch: A Case Report of Acral Fibromyxoma

Monica Mishra*, Kailas Mulsange, Gunvanti Rathod and Deepthi Konda

Published: 07 April, 2025 | Volume 9 - Issue 1 | Pages: 005-007

Background: Acral Fibromyxoma (AFM) is a rare benign soft tissue tumour which is described as a fibromatous and myxoid tumour of skin and soft tissue. 
Case details: A 40-year-old  male presented to the Dermatology outpatient department with swelling over the wrist of one year duration. The swelling was associated with mild pain, and it gradually increased in size to reach its present size. Cutaneous examination revealed a 2x2 cm mobile, cystic to firm, non-tender swelling over the dorsum of the right wrist. Based on its location and clinical features, it was provisionally diagnosed as a ganglion cyst  and excision biopsy was done. Histology showed stellate-shaped cells in a myxoid background with round to oval nuclei having a small, inconspicuous nucleolus. Acral fibromyxoma presents a distinct histopathology including a myxoid stroma and spindle-shaped cells, which are essential for accurate diagnosis and management.

Read Full Article HTML DOI: 10.29328/journal.apcr.1001045 Cite this Article Read Full Article PDF

Keywords:

Acral fibromyxoma; CD 34; SMA; S-100

References

  1. Tan HL, Ahmad TS, Sankara Kumar C, Khirusman Adnan Y, Looi LM, Gunasagaran J. Superficial acral fibromyxoma: insights from case management and comprehensive literature review. EFORT Open Rev. 2024 Feb 1;9(2):129–137. Available from: https://doi.org/10.1530/eor-23-0151
  2. Dehner CA, Pearson H, Almohsen SS, Lo YC, Thangaiah JJ, Torres-Mora J, et al. Acral Fibrochondromyxoid Tumour: A Clinicopathologic and Molecular Genetic Study of 37 Cases. Mod Pathol. 2024 Dec;37(12):100599. Available from: https://doi.org/10.1016/j.modpat.2024.100599
  3. Goo J, Jung YJ, Kim JH, Lee S Yul, Ahn SK. A case of recurrent superficial acral fibromyxoma. Ann Dermatol. 2010;22(1):110–113. Available from: https://doi.org/10.5021/ad.2010.22.1.110
  4. Debordes PA, Hamoudi C, Weingertner N, Di Marco A. Superficial acral fibromyxoma: a case of missed diagnosis. J Surg Case Rep. 2023 Feb 1;2023(2):rjad027. Available from: https://doi.org/10.1093/jscr/rjad027
  5. Fetsch JF, Laskin WB, Miettinen M. Superficial acral fibromyxoma: a clinicopathologic and immunohistochemical analysis of 37 cases of a distinctive soft tissue tumour with a predilection for the fingers and toes. Hum Pathol. 2001 Jul;32(7):704–714. Available from: https://doi.org/10.1053/hupa.2001.25903

Figures:

Figure 1

Figure 1

Figure 1

Figure 2

Figure 1

Figure 3

Figure 1

Figure 4

Similar Articles

Recently Viewed

Read More

Most Viewed

Read More

Help ?